Determination of the influence of process variables on the dissolution of gastro-resistant microcapsules of diclofenac produced by ionic gelation using 2K factorial design

Authors

  • National Autonomous University of Nicaragua, León
  • National Autonomous University of Nicaragua, León

DOI:

https://doi.org/10.5377/universitas.v8i1.14143

Keywords:

Microcapsules, Gas -resistant, Diclofenac, Design of Experiments, Sodium alginate, Calcium chloride, Polymer

Abstract

The influence of process factors on the dissolution of diclofenac gastro-resistant microcapsules was evaluated, such as: polymer concentration, dripping height and washing time. For the study, a 2k factorial design of experiments was used, 3 factors at 2 different levels.

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Author Biographies

, National Autonomous University of Nicaragua, León

Faculty of Chemical Sciences Department of Pharmaceutical Technology

, National Autonomous University of Nicaragua, León

Faculty of Chemical Sciences Department of Pharmaceutical Technology

References

Fda.gov. (2016). Guía para la Industria: Pruebas de disolución de formas de dosificación oral sólidas de liberación inmediata. [online] Available at:

http://www.fda.gov/Drugs/GuidanceComplianceRegulatoryInformation/Guidances/ucm200707.htm [Accessed 16 Sep. 2016].

Mazinger.sisib.uchile.cl. (2016). Factores que influyen en la Biodisponibilidad. [online] Available at: http://mazinger.sisib.uchile.cl/repositorio/lb/ciencias_quimicas_y_farmaceuticas/cide02/capitulo06/02.html [Accessed 16 Sep. 2016].

Remington: Farmacia, Volumen 1. Alfonso R. (DRT) Gennaro. Ed. Médica Panamericana, 2003. Pag 1157

Martín Villena MJ, Morales Hernández, ME, Gallardo Lara V y Ruiz Martínez MA. Técnicas de microencapsulación: una propuesta para microencapsular probióticos.

Alginate in Drug Delivery Systems.Hanne Hjorth Tønnesen and Jan Karlsen.Drug Development and Industrial Pharmacy Vol. 28 , Iss. 6,2002

https://doi.org/10.1081/DDC-120003853

Juan Ramón García. Introducción a los diseños factoriales. http://documents.mx/documents/introduccion-a-los-disenos-factoriales-558dd67d035b9.html. Consultada 18 septiembre de 2016.

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Published

2017-07-01

How to Cite

Eveling, & José. (2017). Determination of the influence of process variables on the dissolution of gastro-resistant microcapsules of diclofenac produced by ionic gelation using 2K factorial design. Universitas (León): Revista Científica De La UNAN León, 8(1), 1–4. https://doi.org/10.5377/universitas.v8i1.14143

Issue

Vol. 8 No. 1 (2017)

Section

Articles

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Copyright (c) 2017 National Autonomous University of Nicaragua, Leon

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