Effect of Propolis and Apitoxin from Honey Bee (Apis mellifera scutellata) on the wound healing process in animals
DOI:
https://doi.org/10.5377/universitas.v15i2.18850Keywords:
apitoxin, healing, wound, hamster propolis.Abstract
Propolis and apitoxin are natural substances produced by bees, they have bactericidal and regenerative properties, they do not generate bacterial resistance. These substances contain peptides and flavonoids that promote the epithelial regeneration process by stimulating the events that participate in the healing process. In the present study, the effectiveness of Propolis Ethyl Extract (EEP) and honey bee Apitoxin (Apis mellifera scutellata) in hamsters was determined, as a natural alternative treatment in the wound healing process. The groups were made up of 5 hamsters, group 1 and 2 (control, Physiological Saline Solution), group 3 (EEP at 10 %), group 4 (EEP at 20%), group 5 (EEP at 30 %), group 6 ( apitoxin), group 7 (aloe vero) and group 8 (ointment). A one-centimeter ovoid incision was made on each specimen with a sterile scalpel, under anesthesia and with prior disinfection of the area. Daily wound measurements were taken on each hamster and the complete healing process was observed for 16 days. The post hoc Games-Howells test was applied for multiple comparisons, where no significant statistical differences were found between the propolis treatments. When performing the Mann Whitney U statistical test, it was determined that there is a statistically significant difference for the treatments (Apitoxina, Aloe vera and Ointment), corresponding to the size of the wound between the treatments, with a significance value of P < 0.017, having Apitoxin, a better effect on the wound healing process.
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