Physical and mental effects in older adults due to prolonged use of benzodiazepines

Authors

DOI:

https://doi.org/10.5377/alerta.v8i3.18116

Keywords:

Substance-Related Disorders, Aging, Benzodiazepines, Metabolic Side Effects of Drugs and Substances, Quality of Life

Abstract

The potential effects and risks of benzodiazepine use have been documented for several decades, with older adults being particularly affected due to the significant changes in pharmacokinetics and pharmacodynamics associated with aging. The objective of this narrative review was to provide answers regarding the effects of benzodiazepine use on the physical and mental health of older adults. A search was conducted in PubMed, Cochrane, Scielo, and LILACS, as well as in the repository of the Library, Documentation, and Information System of the University of Costa Rica. The effects on physical health identified were an increased risk of falls and fractures, while in mental health, an increased risk of dementia and decreased cognitive processing speed were reported. The results emphasize the importance of limiting the prolonged use of benzodiazepines in older adults and promoting non-pharmacological therapeutic alternatives, such as cognitive-behavioral therapy, especially for the management of insomnia and anxiety. Raising awareness among those who prescribe this type of medication is essential so that they seek alternative ways to address conditions such as insomnia and anxiety in this population.

Downloads

Download data is not yet available.
Abstract
810
PDF Español (Español (España)) 175
PDF English 40

References

Celikkayalar E, Airaksinen M, Liisa S, Nieminen J, Kleme J, Puustinen J. Are Older People Aware of Potential Risks Related to Benzodiazepines They are Taking and Has Anything Changed in Risk Awareness Over Ten Years? Patient Preference and Adherence. 2021; 15:141-147.

Robles A, Gude F. Prescripciones inconvenientes en el tratamiento del paciente con deterioro cognitivo. Neurología. 2014;29(9):523—532.

Billioti S, Bégaud B, Bazin F, Verdoux H, Dartigues J, Pérès K et al. Uso de benzodiazepinas y riesgo de demencia: estudio poblacional prospectivo. BMJ 2012; 345: e6231.

Wolter DK. Benzodiazepina absetzen im Alter. Gerontol Geriat. 2017; 50(2): 115-122.

Lynch T, Ryan C, Hughes CM, Presseau J, van Allen ZM, Bradley CP, et al. Brief interventions targeting long-term benzodiazepine and Z-drug use in primary care: a systematic review and meta-analysis. Addiction. 2020;115(9):1618-1639.

Román P, Ruiz-Cantero A. La pluripatología, un fenómeno emergente y un reto para los sistemas sanitarios. Revista Clínica Española. 2017; 217(4): 229-237

By the 2019 American Geriatrics Society Beers Criteria® Update Expert Panel. American Geriatrics Society 2019 Updated AGS Beers Criteria® for Potentially Inappropriate Medication Use in Older Adults. J Am Geriatr Soc. 2019; 67(4):674-694.

Liu L, Jia L, Jian P, Zhou Y, Zhou J, Wu F, et al. The Effects of Benzodiazepine Use and Abuse on Cognition in the Elders: A Systematic Review and Meta-Analysis of Comparative Studies. Front Psychiatry. 2020; 11:00755.

Cubero-Alpízar C, Rojas-Valenciano L, Campos-Fernández M, Hernández-Soto LE. Prescripciones de benzodiacepinas y barbitúricos en Costa Rica 2011-2015. Horizonte Sanitario. 2020; 19(2): 277-290.

Cubero C, Rojas L, Campos M, Hernández LE. Prescripción de clonazepam en Costa Rica. Revista española de drogodependencias. 2018; 43(3), 2018: 39-55.

Cubero C, Rojas L, Campos M. Prescripción de Lorazepam dentro de la Caja Costarricense del Seguro Social. J. Health NPEPS. 2019; 4(2): 70-89.

Hofmann W. Benzodiazepine in der Geriatrie [Benzodiazepines in geriatrics]. Gerontol Geriatr. 2013; 46(8):769-76.

Ray W, Chung C, Murray K, Malow B, Daugherty J, Stein M. Mortality and concurrent use of opioids and hypnotics in older patients: A retrospective cohort study. PLoS Med. 2021; 18(7):1-17.

Organización Mundial de la Salud. Acción multisectorial para un envejecimiento saludable basado en el ciclo de la vida: proyecto de estrategia y plan de acción mundiales sobre el envejecimiento y la salud. 2016.

Organización Panamericana de la Salud (OPS). Década de Envejecimiento Saludable (2021-2030).

Peters MDJ, Godfrey C, McInerney P, Munn Z, Tricco AC, Khalil, H. Chapter 11: Scoping Reviews (2020 version). In: Aromataris E, Munn Z (Editors). JBI Manual for Evidence Synthesis, JBI, 2020.

Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, et al. The PRISMA 2020 statement: An updated guideline for reporting systematic reviews. J Clin Epidemiology. 2021; 134:178-189.

Pietrzak RH, Scott JC, Harel BT, Lim YY, Snyder PJ, Maruff, P. A process-based approach to characterizing the effect of acute alprazolam challenge on visual paired associate learning and memory in healthy older adults. Hum. Psychopharmacol Clin Exp. 2012; 27: 549-558.

Zhong G, Wang Y, Zhang Y, Zhao Y. Association between Benzodiazepine Use and Dementia: A Meta-Analysis. PLoS One. 2015; 10(5)

Poly TN, Islam MM, Yang HC, Li YJ. Association between benzodiazepines use and risk of hip fracture in the elderly people: A meta-analysis of observational studies. Joint Bone Spine. 2020; 87(3):241-249.

Díaz-Gutiérrez MJ, Martínez-Cengotitabengoa M, Sáez E, Cano AI, Martínez-Cengotitabengoa MT, Besga A, et. al. Relationship between the use of benzodiazepines and falls in older adults: A systematic review. Maturitas. 2017; 101:17-22.

Gómez S, León T, Macuer M, Alves M, Ruiz S. Uso de benzodiazepinas en adultos mayores en América Latina [Benzodiazepine use in elderly population in Latin America]. Rev Med Chil. 2017;145(3):351-359.

Kim HB, Myung SK, Park YC, Park B. Use of benzodiazepine and risk of cancer: A meta-analysis of observational studies. Int J Cancer. 2017; 140(3):513-525.

Nafti M, Sirois C, Kröger E, Carmichael P-H, Laurin D. Is Benzodiazepine Use Associated With the Risk of Dementia and Cognitive Impairment–Not Dementia in Older Persons? The Canadian Study of Health and Aging. Annals of Pharmacotherapy. 2020;54(3):219-225.

Young M, Jung W, Lee E, Kim C, Joon S, Sook J, et al. Association between use of benzodiazepines and occurrence of acute angleclosure glaucoma in the elderly: A population-based study. Journal of Psychosomatic Research. 2019; 1-5.

Hosseinzadeh B, Doustmohammadi H, Mokhtari T, Abdollahpour A. Benzodiazepines related sexual dysfunctions: A critical review on pharmacology and mechanism of action. Revista Internacional de Andrología. 2021; 19 (1): 62-68.

Millán JC. Principios de geriatría y gerontología. Madrid: McGraw-Hill; 2006

Lapeyre-Mestre M. A Review of Adverse Outcomes Associated with Psychoactive Drug Use in Nursing Home Residents with Dementia. Drugs Aging. 2016; 33(12):865-888.

Ram B, Lee E, Seuk B, Hoon S, Kang YJ, Jung SY. Risk of fracture in antidepressant users with concurrent use of benzodiazepines: A self-controlled case-series analysis. Bone. 2021; 3-8.

Arriola I, Santos J, Martínez N, Barona C, Martínez-González JM. Consideraciones farmacodinámicas y farmacocinéticas en los tratamientos habituales del paciente gerodontológico. Av Odontoestomatol. 2009; 25( 1 ): 29-34.

Published

2025-07-31

How to Cite

Cubero Alpízar, C., Medina Arias, K., & Villalobos Núñez, B. (2025). Physical and mental effects in older adults due to prolonged use of benzodiazepines. Alerta, Revista científica Del Instituto Nacional De Salud, 8(3), 290–296. https://doi.org/10.5377/alerta.v8i3.18116

Issue

Section

Review article

Similar Articles

1 2 3 4 5 6 7 8 9 10 > >> 

You may also start an advanced similarity search for this article.