Histological analysis of the biocompatibility of sealapex root canal sealant cement in laboratory mice
DOI:
https://doi.org/10.5377/creaciencia.v0i11.8146Keywords:
Sealapex, calcium hydroxide, laboratory mice, histological evaluation, calcifications, El SalvadorAbstract
The present in-vivo study was performed by histological analysis; to evaluate the biocompatibility of Sealapex Endodontic Sealant Cement, upon contact with connective tissue in laboratory mice.
This connective tissue has a great similarity with the periodontal tissues of the teeth, that is why mice were selected and thus have a better information on how calcium hydroxide (Sealapex cement) acts within the dental tissues when performing a root canal treatment.
The sample investigated was of 5 isogenic mice of the same sex; which, through a surgical intervention, were implanted subcutaneously in the connective tissue, a 1 cm long polyethylene tube containing the Cement to be investigated.
The sample was held in captivity and sacrificed in controls of 3, 7, 14,21 and 28 days. The findings were classified according to according to the degree of inflammation, fibrosis and mineralization, which presented the connective tissue against Sealapex endodontic sealant cement and demonstrated that the degree of compatibility of Sealapex sealant cement was acceptable in all cases evaluated.
The moderate fibrosis adhered to the tube containing the cement, is indicative of a good tolerance of the subcutaneous connective tissue of mice towards the product.
Similarly, it has the property of inducing the formation of mineralizations, which were detected on the connective tissue of laboratory mice.
(Promoting its alkaline pH that allows release of hydroxyl ions (OH-), unlike the acidic pH that would increase its inflammation and the lack of compatibility of sealant cement with periodontal tissues).
Therefore, it is recommended for cases of endodontically treated parts with pulp necrosis or vital pulps.
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