Scale up proposal for the spray drying process of hebernem-s bionematicide

Authors

  • Yunier L. Paneque Diaz Center of Genetic Engineering and Biotechnology, Department of Research and Development, Camagüey, Cuba
  • Rutdali M. Segura Silva Center of Genetic Engineering and Biotechnology, Department of Research and Development, Camagüey, Cuba
  • Nemecio González Fernández Center of Genetic Engineering and Biotechnology, Department of Research and Development, Camagüey, Cuba
  • Jesús Zamora Sánchez Center of Genetic Engineering and Biotechnology, Department of Production, Camagüey, Cuba
  • Eikel Pérez González Center of Genetic Engineering and Biotechnology, Department of Production, Camagüey, Cuba
  • Lourdes M. respo Zafra University of Camagüey, Faculty of Applied Sciences, Camagüey, Cuba
  • Aylin Nordelo Valdivia Center of Genetic Engineering and Biotechnology, Department of Research and Development, Camagüey, Cuba
  • Amaury Pérez Sánchez University of Camagüey, Faculty of Applied Sciences, Camagüey, Cuba

DOI:

https://doi.org/10.5377/nexo.v36i05.17309

Keywords:

Sauter diameter, Efficiencies, Scale-up, Spray drying, Mathematical model, Enthalpies

Abstract

The need for robust spray dryer scale-up methods is essential to control critical quality attributes in the biopharmaceutical industry. In this second part, various parameters are determined such as the heat capacity of the cream (value of 3.626 kJ/kg.ºC), the enthalpies and mass flowrates of the different streams involved, the Sauter diameter (88.78 μm), the drying total time (6.90 s) and the efficiencies. A mathematical model was also obtained by using MATLABÒ software, in order to determine the main phenomenological characteristics of the evaluated spray drying process. In general, the increase in the cream feeding temperature, the powder temperature, the cream dry mass and the rotation speed of the atomizer decrease the final humidity of the powder, while the air inlet temperature and the absolute air humidity increase it. The temperature of the powder at the exit of the cyclone and the rotation speed of the atomizer disk are the variables that most influence the scale-up of spray drying. The new mathematical model obtained in this work quantitatively describes the spray-drying process of HeberNem-SÒ bionematicide.

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Published

2023-11-30

How to Cite

Paneque Diaz, Y. L., Segura Silva, R. M., González Fernández, N., Zamora Sánchez, J., Pérez González, E., respo Zafra, L. M. ., Nordelo Valdivia, A., & Pérez Sánchez, A. (2023). Scale up proposal for the spray drying process of hebernem-s bionematicide. Nexo Scientific Journal, 36(05), 193–218. https://doi.org/10.5377/nexo.v36i05.17309

Issue

Vol. 36 No. 05 (2023): In commemoration of the 40th anniversary of the founding of the National University of Engineering

Section

Articles

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Copyright (c) 2023 Universidad Nacional de Ingeniería

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