An update on the detection of tuberculosis through molecular testing
DOI:
https://doi.org/10.5377/alerta.v7i2.17129Keywords:
Mycobacterium Tuberculosis, Tuberculosis, Diagnosis, Molecular TestsAbstract
Tuberculosis is a respiratory infectious disease that affects one third of the world's population and is a significant threat to global health. Detecting tuberculosis early is crucial for effective treatment and preventing its spread. One solution to improve diagnosis and address antituberculosis drug resistance is the use of high-throughput molecular tests for the identification of Mycobacterium tuberculosis and its susceptibility. This narrative review study seeks to describe the generalities, efficacy, sensitivity, advantages and limitations of the main molecular tests: Truenat® MTB, MTB plus and MTBRIF, Abbott RealTime MTB and MTB RIF/INH on the m2000sp and m2000rt system and FluoroType MTBDR, and to compare them with GeneXpert MTB/RIF or Xpert Ultra, used for the detection of the tuberculosis drug-resistant pathogen. These tests use various techniques for the detection of Mycobacterium tuberculosis DNA and quantification of bacterial load with high sensitivity and specificity, rapid results, reduction of human error, as well as early detection of drug-resistant strains.
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Copyright (c) 2024 Laura Sanchez Figueroa, Valeria Guillen Muñoz, Juan Diego Pérez Pérez, Pablo Rodríguez Abrego, Claudia Caprile Mata, Katherine Cartagena López
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