Antimicrobial susceptibility profiles of extended-spectrum beta-lactamase-producing bacteria

Abstract

Introduction. Bacterial resistance is a global problem, as bacteria such as Escherichia coli and Klebsiella pneumoniae have increasingly high resistance rates. Objective. Describe profile of antimicrobial susceptibility and the characteristics of patients with infection by the bacteria Escherichia coli and/or Klebsiella pneumoniae producing extended-spectrum beta-lactamases in two hospitals in the public network of El Salvador, 2022. Methodology.  Descriptive study of the characteristics and antimicrobial susceptibility profiles of a retrospective cohort with 989 patients who were infected with Escherichia coli and/or Klebsiella pneumoniae is presented. Results. The 50,1 % had an infection by Escherichia coli and/or Klebsiella pneumoniae bacteria that produce extended-spectrum Beta-lactamases and 34,1 % of these died in the 30-day follow-up. For these bacteria the percentage of resistant susceptibility was 46,0 % and 13,0 % respectively. The percentages of resistance were higher for ampicillin (100 %) and ceftriaxone (43 % to 98 %), although carbapenems also showed resistance (3 % to 5 %). Conclusion. Serious complications and outcomes were more frequent in patients with infection by extended-spectrum Beta-lactamases-producing bacteria and these showed greater resistant susceptibility to cephalosporins and penicillins.