Respiratory failure in a patient with Sézary syndrome
DOI:
https://doi.org/10.5377/alerta.v6i2.16211Keywords:
Lymphoma, Sezary Syndrome, Mycosis Fungoides, Dermatitis ExfoliativeAbstract
Case presentation. A 44 year old female patient, with no preexisting underlying disease, with a history of approximately ten months of presenting pruritic erythematous-desquamative lesions initially localized in the lower extremities and later generalized throughout the body, associated with weight loss of 15 kg. Treatment. Initial management consisted of topical corticosteroids and oral antihistamines with little clinical response. A dermatology work-up was initiated, and the initial diagnosis of malignant T-cell neoplasm was confirmed. A bone marrow smear was performed, in which "cerebriform" cells were identified, confirming the diagnosis of Sézary syndrome. The patient received cyclophosphamide, doxorubicin, vincristine, etoposide, and prednisone chemotherapy. Outcome. The initial response was favorable, with hospital discharge and outpatient follow-up. After three months of treatment, the patient consulted for a febrile episode, productive cough plus respiratory distress associated with bilateral basal rales, presented respiratory failure, and during induction of mechanical ventilation suffered cardiorespiratory arrest and died.
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Copyright (c) 2023 Neftalí Alexander Granados Flores, Gerson Jonathan Castillo Hernández, Rafael Antonio Trejo Ayala
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