Susceptibility to ciprofloxacin in non- multidrug resistant Salmonella Typhi, 2017 to 2020

Abstract

Introduction. The antimicrobial susceptibility patterns of Salmonella enterica serotype Typhi have changed globally during the last three decades. Objective. Describe the antimicrobial susceptibility patterns of Salmonella enterica Typhi isolates, registered in El Salvador from January 2017 to June 2020. Methods. A secondary evaluation of the National Public Health Laboratory Salmonella enterica Typhi databases was realized, with their respective antibiograms, using samples from patients who presented enteric fever in El Salvador, from January 2017 to June 2020. Results. 1406 Salmonella enterica Typhi isolates were reported. 100% of the analyzed isolates were susceptible to ceftriaxone and azithromycin. 99,9% of the analyzed isolates were susceptible to ampicillin, chloramphenicol, tetracycline and trimethoprim-sulfametoxazol. For ciprofloxacin, susceptibility was detected in 8,5% of the analyzed strains, intermediate susceptibility in 91,5% and resistance in 0,08%. Conclusion. The findings are compatible with what has been reported worldwide: the rapid development of intermediate susceptibility or resistance to ciprofloxacin, once it ́s adopted as the treatment of choice for enteric fever. In El Salvador, antibiotics previously considered as first-line options against Salmonella enterica Typhi, must be recycled.